Oleic Acid-PVA Based Amphiphilic Polymer Micelles for Vitamin D Encapsulation

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Journal of the Turkish Chemical Society Section A: Chemistry
Volume:10 Issue:4
Oleic Acid-PVA Based Amphiphilic Polymer Micelles for Vitamin D Encapsulation

Oleic Acid-PVA Based Amphiphilic Polymer Micelles for Vitamin D Encapsulation

Pages : 1055-1062

View : 72 | Download : 88

Publication Date : 2023-11-11

Article Type : Research Paper

Abstract :In this study, oleic acid-PVA based amphiphilic polymer micelles were prepared for vitamin D encapsulation. The amphiphilic polymer encapsulations were characterized using Fourier transformed infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy (1H-NMR). The goal of the study was to create micelles by using a lipophilic and biocompatible polymer. An oleic acid-substituted polyvinyl alcohol polymer was created through an acidic esterification reaction. The chemical structure of the polymer was disclosed by FTIR. To calculate the polymer\'s substitution ratio, 1H-NMR was used. Micellization was used to encapsulate vitamin D. Scanning electron microscope (SEM) analysis was used to determine the crucial micelle concentration and the size of the oleic acid-modified PVA. Ultraviolet–visible (UV) spectroscopy was used to analyze the release of vitamin D at various pH levels. As a result, vitamin D can be enclosed in PVA polymer that has been substituted with oleic acid.
Keywords : Encapsulation, Vitamin D, Oleic Acid, Drug Release, Micelle

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