Synthesis, spectroscopic characterization, crystal structure and DNA docking studies of a new trans-platinum saccharinate complex containing aqua and dimethyl sulfoxide ligands

Authors : Ceyda İçsel Yılmaz

Pages : 683-690

Doi:10.18596/jotcsa.1399962

View : 32 | Download : 69

Publication Date : 2024-05-15

Article Type : Research Paper

Abstract :A new trans-platinum complex, trans-[Pt(sac)2(H2O)(DMSO)] (sac= saccharinate; DMSO= dimethyl sulfoxide), was synthesized and characterized by elemental analysis, UV, FTIR, NMR spectroscopy and X-ray single-crystal diffraction. In the mononuclear complex, the platinum(II) cation was coordinated by two N-coordinated sac ligands in the trans position, the sulfur atom of the DMSO ligand, and an aqua ligand, forming a distorted square planar coordination geometry. The interaction of the platinum(II) complex with DNA was studied using molecular docking. The complex successively docked into the minor groove of DNA via intermolecular hydrogen bonds with the adenine, cytosine, and guanine bases.
Keywords : Platinum II complex, saccharinate, X ray crystallography, DNA docking