Determination of Irbesartan in Pharmaceutical Preparations by Polarographic Methods

Authors : Bilal Yılmaz, Aytekin Korkmaz, Semih Yılmaz, Yücel Kadıoğlu

Pages : 1081-1090

Doi:10.18596/jotcsa.1387493

View : 36 | Download : 81

Publication Date : 2024-08-30

Article Type : Research Paper

Abstract :In this study, the polarographic behavior of irbesartan was investigated using the cyclic polarographic method. A mercury drop electrode was used to quantify the peak currents in comparison to Ag/AgCl at 0.10 V/s. Additionally, quick and easy square wave and differential pulse polarographic methods were developed and validated to determine irbesartan in pharmaceutical preparations. For both methods, the calibration curves were linear at concentrations between 5 and 70 μg/mL. The precision was given by relative standard deviation and was less than 2.61%. Accuracy was given with relative error and did not exceed 1.24%. The suggested methods are extremely accurate and precise. No interference was found under the chosen experimental conditions. In pharmaceutical preparations, irbesartan had an average recovery of 99.8%. Therefore, the methods are applicable to the determination of irbesartan in pharmaceutical preparations.
Keywords : Irbesartan, Polarography, Validation, Tablet