Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review

Authors : Rebaz OMER, Rzgar Farooq RASHİD, Khdir OTHMAN

Pages : 43-56

Doi:10.54565/jphcfum.1263834

View : 37 | Download : 28

Publication Date : 2023-06-21

Article Type : Review Paper

Abstract :The pharmacological activities of triazole derivatives have been studied extensively by researchers. Different derivatives of triazole have showed promise in treating various diseases. Most triazole derivatives have demonstrated anti-inflammatory, anti-cancer, anti-bacterial and anti-fungal activities. The ability of these compounds to modulate various biological processes has made them attractive for pharmaceutical development. Furthermore, the low cost and wide availability of triazoles have made them even more attractive for drug development. In addition to the pharmacological activities, triazole derivatives have also been reported to possess antioxidant properties. Studies have shown that 1,2,3-triazole can protect against oxidative damage and inhibit lipid peroxidation. Furthermore, 1,2,4-triazole has been found to act as an antioxidant and scavenge free radicals. The antioxidant properties of triazoles make them attractive for the development of new drugs. The synthesis of triazole derivatives has also been studied extensively. Various methods have been developed to synthesize triazole derivatives, including chemical and enzymatic methods. Chemical methods involve the formation of cyclic structures by the reaction of alkyl halides with azides. Enzymatic methods involve the use.
Keywords : Synthesis, 1, 2, 4 Triazole Derivatives, Triazole derivatives, Triazole substituted