Acute Effect of Centrally Injected Nesfatin-1 on Some Blood Electrolytes and Metabolites in Rats

Authors : Gökçen GÜVENÇ BAYRAM, Ebru YALÇIN ÜLGER, Murat YALÇIN

Pages : 149-152

Doi:10.30782/jrvm.735993

View : 19 | Download : 2

Publication Date : 2020-12-30

Article Type : Research Paper

Abstract :Nesfatin-1 is a newly found food and water intake regulatory neuropeptide. Because it can regulate nutrition and thirst, nesfatin-1 may also have the potential to affect levels of blood electrolytes and metabolites. The current study was intended to resolve the acute influence of intracerebroventricularly injected nesfatin-1 on the levels of some blood electrolytes and metabolites in rats. The experiments were conducted on Sprague Dawley male rats. Nesfatin-1 insert ignore into journalissuearticles values(200 pmol); or saline insert ignore into journalissuearticles values(5 μL); was given the rats intracerebroventricularly. Central nesfatin-1 treatment caused increases in the concentrations of blood glucose, lactate, hematocrit, and hemoglobin without changing the blood pH, creatine, Na, K, Ca, Cl, and HCO3 levels. In conclusion, our findings show that the central nesfatin-1 could affect the concentrations of blood glucose, lactate, hematocrit, and hemoglobin without altering the blood electrolytes. This could be interpreted as the secondary effect of nesfatin-1 as a consequence of centrally injected nesfatin-1-evoked activation of sympathetic nerves.
Keywords : Nesfatin 1, Intracerebroventricular, Blood electrolytes, Blood metabolites, Hematocrit, Hemoglobin