Synthesis of macrocyclization cyclophanes and their metal complexes, characterization and antimicrobial activity

Authors : Murat TURKYİLMAZ, Murat DÖNMEZ, Murat ATES

Pages : 27-34

Doi:10.47481/jscmt.1253033

View : 18 | Download : 13

Publication Date : 2023-03-31

Article Type : Research Paper

Abstract :Due to their chemical properties, cyclophane-type compounds constitute an interesting organic chemistry class. In the structure of all cyclic compounds, macrocyclization is the most critical issue for high-efficiency synthesis. Especially with a small cyclophane structure, the experimental steps are more complicated than with a prominent cyclophane structure. In this manuscript, three different material groups were applied to synthesize silver cyclophane compounds for smart drug properties. In the first material group, 5,6-dimetil-1H-benzo[d] imidazole insert ignore into journalissuearticles values(1); and 2,6-bisinsert ignore into journalissuearticles values(chloromethyl);pyridine insert ignore into journalissuearticles values(2); were reacted to form 5,6-dimethyl-1- insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(6-insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(5,6-dimethyl-1H-benzo[d]imidazole-1-il);methyl);pyridine-2-il);methyl);-1H-benzo[d] imidazole compound insert ignore into journalissuearticles values(3);. In the second material group, ethyl 2-bromoacetate insert ignore into journalissuearticles values(4); reacted to different nitrogen atoms of the cyclophane compound to form a symmetric carbene compound, which is water-soluble insert ignore into journalissuearticles values(5);. In the third material group, the silver insert ignore into journalissuearticles values(I); and palladium insert ignore into journalissuearticles values(II); metal complexes were synthesized due to the reaction with silverinsert ignore into journalissuearticles values(I); oxide insert ignore into journalissuearticles values(6); and palladium insert ignore into journalissuearticles values(II); chloride insert ignore into journalissuearticles values(7);. Antimicrobial activities of the carbene compounds and silver and palladium complexes insert ignore into journalissuearticles values(5, 6, and 7); were investigated against bacteria and fungal in more detail. Silver insert ignore into journalissuearticles values(I); complex insert ignore into journalissuearticles values(6); shows an antimicrobial agent when mixed with microorganisms, such as Gram-positive, Gram-negative, and fungal, but this property has not been observed in the palladium insert ignore into journalissuearticles values(II);-carbene complex insert ignore into journalissuearticles values(7);.
Keywords : carbene, cyclophane, metal complexe