VOLTAMMETRIC DETERMINATIN OF CLOZAPINE FROM ITS DRUG FORM

Authors : Reyhan EKER, Selehattin YILMAZ, Sultan YAĞMUR, Özlem TONGUÇ YAYINTAŞ

Pages : 19-30

View : 11 | Download : 7

Publication Date : 2017-06-01

Article Type : Research Paper

Abstract :A voltammetry method was developed for the direct quantitative determination of clozapine in tablet dosage forms based on its oxidation behavior. The electrochemical determination of clozapine was easily carried out on glassy carbon electrode insert ignore into journalissuearticles values(GCE); using a variety of voltammetry techniques. The electrochemical measurements were carried out on GCE in various buffer solutions in the pH range from 3.00 to 12.00 by cyclic voltammetry insert ignore into journalissuearticles values(CV); and differential pulse voltammetry insert ignore into journalissuearticles values(DPV); techniques. The dependence of pH on the anodic peak current and peak potential was investigated. Acetate buffer insert ignore into journalissuearticles values(pH 5.50); was selected for analytical purposes. The diffusion-controlled nature of the peak was established. A linear calibration curve for DPV analysis was constructed in the clozapine concentration range from 3x10-6 mol L-1 to 1x10-5 mol L-1. Limit of detection insert ignore into journalissuearticles values(LOD); and limit of quantification insert ignore into journalissuearticles values(LOQ); were obtained as 4.082x10-7 mol L-1 and 1.361x10-6 mol L-1 respectively. Validation of applied voltammetric techniques was checked with recovery studies.
Keywords : clozapine, determination, voltammetry, GCE, drug forms