DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY

Authors : Elif UĞURLU, Sultan YAĞMUR, Selehattin YILMAZ

Pages : 1-8

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Publication Date : 2018-01-31

Article Type : Research Paper

Abstract :In this study, electroanalytical technique was developed for the quantitative analysis of clomipramine hydrochloride from its commercial tablet dosage forms based on its oxidation behavior. The electrochemical determination of clomipramine hydrochloride was easily carried out on glassy carbon electrode insert ignore into journalissuearticles values(GCE); by two voltammetric techniques.  The electrochemical measurements were carried out on GCE surface in different buffer solutions in the pH range from 2.00 to 12.00 by cyclic voltammetry insert ignore into journalissuearticles values(CV); and differential pulse voltammetry insert ignore into journalissuearticles values(DPV); techniques.  The effect of pH on the anodic peak current and peak potential was investigated. Phosphate buffer insert ignore into journalissuearticles values(pH 6.50); was selected for analytical purposes.  The diffusion-controlled nature of the peak was obtained.   A linear calibration plot for DPV analysis was constructed in the clozapine concentration range from 5x10 -6 mol L -1 to 3x10 -5 mol L -1 . Limit of detection insert ignore into journalissuearticles values(LOD); and limit of quantification insert ignore into journalissuearticles values(LOQ); were obtained as 2.8x10 -7 mol L -1 and 8.4x10 -7 mol L -1 respectively. 
Keywords : clomipramine hydrochloride, oxidation, voltammetry, GCE