SPECTROMETRIC DETERMINATION OF ROSUVASTATIN AND EZETIMIBE IN TABLETS BY MULTIVARIATE CALIBRATION

Authors : Hakan AKTAŞ, Ümit UÇAR

Pages : 1-12

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Publication Date : 2018-05-01

Article Type : Research Paper

Abstract :Two multivariate calibration-prediction techniques, principal component analysis insert ignore into journalissuearticles values(PCR); and partial least squares insert ignore into journalissuearticles values(PLS); were applied to the spectrometric multicomponent analysis of the drug containing rosuvastatin insert ignore into journalissuearticles values(ROS); and ezetimibe insert ignore into journalissuearticles values(EZE); without any separation step. The selection of variables was studied. A series of synthetic solution containing different concentrations of ROS and EZE were used to check the prediction ability of the PCR and PLS. The results obtained in this investigation strongly encourage us to apply these techniques for a routine analysis and quality control of the two drugs.
Keywords : rosuvastatin, ezetimibe, spectrometry, multivariate calibration