ANTIMICROBIAL ACTIVITY of (E)-3-(4-SULFAMOYLPHENYLCARBAMOYL) ACRYLIC ACID DERIVATIVES

Authors : Halil İLKİMEN, Cengiz YENİKAYA, Aysel GÜLBANDILAR
Pages : 365-375
Doi:10.59313/jsr-a.1126888
View : 28 | Download : 12
Publication Date : 2023-03-29
Article Type : Research Paper
Abstract :In this study, proton transfer salts {insert ignore into journalissuearticles values(Hap);+insert ignore into journalissuearticles values(samal);- insert ignore into journalissuearticles values(4); and insert ignore into journalissuearticles values(HBI);+insert ignore into journalissuearticles values(samal);- insert ignore into journalissuearticles values(5);} were synthesized from the reaction of insert ignore into journalissuearticles values(E);-3-insert ignore into journalissuearticles values(4-sulfamoylphenylcarbamoyl);acrylic acid insert ignore into journalissuearticles values(Hsamal, 1); with 1H-benzimidazole insert ignore into journalissuearticles values(BI, 3); or 2-aminopyridine insert ignore into journalissuearticles values(ap, 2);, metal complexes of 1 {Feinsert ignore into journalissuearticles values(II); {[Feinsert ignore into journalissuearticles values(samal);insert ignore into journalissuearticles values(H2O);2][Feinsert ignore into journalissuearticles values(OH);3insert ignore into journalissuearticles values(H2O);] insert ignore into journalissuearticles values(6); and [insert ignore into journalissuearticles values(H2O);insert ignore into journalissuearticles values(OH);2Feinsert ignore into journalissuearticles values(samal);Feinsert ignore into journalissuearticles values(H2O);2] insert ignore into journalissuearticles values(7);}, Coinsert ignore into journalissuearticles values(II); {[insert ignore into journalissuearticles values(H2O);insert ignore into journalissuearticles values(OH);2Coinsert ignore into journalissuearticles values(samal);Coinsert ignore into journalissuearticles values(H2O);2] insert ignore into journalissuearticles values(8);}, Niinsert ignore into journalissuearticles values(II); {[Niinsert ignore into journalissuearticles values(samal);2insert ignore into journalissuearticles values(H2O);2] insert ignore into journalissuearticles values(9);} and Cuinsert ignore into journalissuearticles values(II); {[Cuinsert ignore into journalissuearticles values(samal);2insert ignore into journalissuearticles values(H2O);2] insert ignore into journalissuearticles values(10);}}, of 4 {Niinsert ignore into journalissuearticles values(II); {[insert ignore into journalissuearticles values(H2O);insert ignore into journalissuearticles values(OH);Niinsert ignore into journalissuearticles values(samal);Niinsert ignore into journalissuearticles values(OH);2insert ignore into journalissuearticles values(ap);insert ignore into journalissuearticles values(H2O);2] insert ignore into journalissuearticles values(11);}, Cuinsert ignore into journalissuearticles values(II); {[Cuinsert ignore into journalissuearticles values(samal);insert ignore into journalissuearticles values(OH);insert ignore into journalissuearticles values(ap);2] insert ignore into journalissuearticles values(12);} and of 5 {Coinsert ignore into journalissuearticles values(II); {[insert ignore into journalissuearticles values(HO);2Coinsert ignore into journalissuearticles values(samal);Coinsert ignore into journalissuearticles values(BI);2] insert ignore into journalissuearticles values(13);}, Niinsert ignore into journalissuearticles values(II); {[insert ignore into journalissuearticles values(H2O);2insert ignore into journalissuearticles values(HO);3Niinsert ignore into journalissuearticles values(samal);Niinsert ignore into journalissuearticles values(BI);2] insert ignore into journalissuearticles values(14);} and Cuinsert ignore into journalissuearticles values(II); {[insert ignore into journalissuearticles values(H2O);2insert ignore into journalissuearticles values(HO);3Cuinsert ignore into journalissuearticles values(samal);Cuinsert ignore into journalissuearticles values(BI);2insert ignore into journalissuearticles values(OH);] insert ignore into journalissuearticles values(15);}} by the methods found in the literature. Antimicrobial activities of 1-15 and metal salts {ironinsert ignore into journalissuearticles values(II); sulfate heptahydrate insert ignore into journalissuearticles values(16);, cobaltinsert ignore into journalissuearticles values(II); acetate tetrahydrate insert ignore into journalissuearticles values(17);, nickelinsert ignore into journalissuearticles values(II); acetate tetrahydrate insert ignore into journalissuearticles values(18); and copperinsert ignore into journalissuearticles values(II); acetate dihydrate insert ignore into journalissuearticles values(19);} against Enterococcus faecalis insert ignore into journalissuearticles values(ATCC 29212); insert ignore into journalissuearticles values(Gram positive);, Pseudomonas aeruginosa insert ignore into journalissuearticles values(ATCC 27853);, Bacillus subtilis insert ignore into journalissuearticles values(wild type);, Staphylococcus aureus insert ignore into journalissuearticles values(NRRL B-767);, Listeria monocytogenes insert ignore into journalissuearticles values(ATCC 7644);, Escherichia coli insert ignore into journalissuearticles values(ATCC 25922); insert ignore into journalissuearticles values(Gram negative); and Candida albicans insert ignore into journalissuearticles values(ATCC 14053); insert ignore into journalissuearticles values(yeast); microorganisms has been tested. The MIC insert ignore into journalissuearticles values(Minimum Inhibitory Concentration); values of 1-19 were compared with those of reference antimicrobial compounds Vancomycin, Cefepime, Levofloxacin and Fluconazole. Compounds with the best activity are 12 insert ignore into journalissuearticles values(15.60 µg/mL); for C. albicans, 1 and 2 insert ignore into journalissuearticles values(31.25 µg/mL); for B. subtilis, 13 insert ignore into journalissuearticles values(31.25 µg/mL); for E. faecalis, 13 insert ignore into journalissuearticles values(15.60 µg/mL); for S. aureus, 4 and 12 insert ignore into journalissuearticles values(15.60 µg/mL); for E. Coli, 3 and 8-12 insert ignore into journalissuearticles values(31.25 µg/mL); for L. monocytogens, and 8 insert ignore into journalissuearticles values(31.25 µg/mL); for P. aeruginoa.
Keywords : 3 4 sulfamoylphenylcarbamoyl, acrylic acid, 2 Aminopyridine, Salt, Metal Complexes, Antimicrobial activity

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