Synthesis, characterization, and investigation of antibacterial and antifungal properties of salt and metal complexes of 2-amino-5-chloropyridine and 2,6-pyridinedicarboxylic acid

Authors : Ayşe Polat, Halil İlkimen, Beyza Yılmaz, Elif Yurt, Aysel Gülbandılar

Pages : 110-120

View : 87 | Download : 58

Publication Date : 2024-06-30

Article Type : Research Paper

Abstract :In this study, the salt (3) of 2-amino-5-chloropyridine (1) and 2,6-pyridinedicarboxylic acid (2) and the complexes of the salt (H1)x[M(2)2].nH2O, M = Fe (III), x = 1, n = 3 (4); M = Co(II), x = 2, n = 4 (5); M = Ni(II), x = 2, n = 5 (6); M = Cu(II), x = 2, n = 4 (7)} were synthesized. The structures of 3-7 were suggested by NMR, AAS, IR, UV, magnetic susceptibility and molar conductivity methods. As a result of spectroscopic analysis, it was observed that all metal complexes had an ionic and octahedral structure. All substances were susceptible to Candida albicans (yeast), Escherichia coli, Bacillus subtilis, Enterococcus faecalis, Pseudomonas aeruginosa, Listeria monocytogenes and Staphylococcus aureus bacteria were examined. Antimicrobial activity results were compared with Fluconazole, Ketoconazole, Chloramphenicol, Levofloxacin, Vancomycin and Cefepime. In the activity results, the best values were observed 3, 5 and 7 in S. aureus bacteria, 1 and 5 in E. coli bacteria, 1, 3 and 7 in P. aeruginoa bacteria, all compounds in L. monocytogenes bacteria, all compounds (except 4) in E. faecalis bacteria, 1 and 3-5 in B. subtilis bacteria and 3, 4 and 7 in C. albicans yeast.
Keywords : 2 Amino 5 chloropyridine, 2, 6 pyridinedicarboxylic acid, salt, metal complex, antimicrobial activity

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