THE EFFECTS OF PLANT ORIGIN EXOSOME EXTRACTS ON A549 AND HCT116 CANCER CELL LINES

Authors : Ayşegül DEMİRHAN, Semra TÜRKOĞLU, Fazilet ERMAN

Pages : 46-58

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Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :By applying the exosomes-like nanoparticles obtained from the leaves of the Gundelia munzuriensis plant on lung cancer insert ignore into journalissuearticles values(A549); and colon cancer insert ignore into journalissuearticles values(HCT116); cell lines, the effects of plant exosomes on cancer cells were investigated. According to our findings, the exosomes incubated with HCT 116 cell lines affected the viability of the cancerous cells by 40-50% compared to control cells. On the other hand, a rate of 50% decrease in A549 cell lines was observed in 24 hours with 250 μg/mL. As a result, our study demonstrates that plant-derived exosomes may be promising therapeutic agents for future cancer treatment, and the research provides an important source for future studies.
Keywords : Nanopartiküller, HCT116, A549, kanser, Gundelia munzuriensis