Effects of Cyanide on Some Histological and Immunohistochemical Parameters of Common Carp (Cyprinus carpio)

Authors : Mustafa Kavasoglu, Kazım Uysal, Ayşenur Değer

Pages : 115-122

Doi:10.17216/limnofish.1183996

View : 225 | Download : 1027

Publication Date : 2023-08-25

Article Type : Research Paper

Abstract :In this study, Bcl 2 and Caspase 3 expressions and histomorphological changes were investigated in the liver, gill and skin tissues of carp (Cyprinus carpio) in which 0,1 mg/L and 0,2 mg/L concentrations of cyanide were added to their environment. It was determined that the lipid accumulation, lymphocyte infiltration, fibrosis and regeneration in the liver tissues; hyperplasia, cell aggregates and goblet cells in the skin epithelium and gill filaments of fish exposed to cyanide. As a result of the study, it was observed that Bcl-2 expressions decreased and caspase-3 expressions increased in all tissues of fish exposed to cyanide at concentrations of 0,1 mg/L and 0,2 mg/L. Changes in Bcl-2 and caspase-3 expression levels result in disruption of the apoptosis mechanism in the liver, gill and skin tissues. At the end of the study, it was concluded that the examined parameters were a good indicator for cyanide intoxication.
Keywords : Cyprinus carpio, siyanür, histoloji

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