The effect of resveratrol on live weight, serum biochemistry and tissue antioxidant enzymes in rats

Authors : Abdullah ÖZBİLGİN, Recep GÜMÜŞ, Mehmet EKİCİ, Nazlı ERCAN
Pages : 112-120
Doi:10.31797/vetbio.1293543
View : 70 | Download : 40
Publication Date : 2023-08-30
Article Type : Research Paper
Abstract :The aim of this study is to determine the effects of resveratrol used in adding it to drinking water. The study was carried out with 24 Wistar albino male 20 days rats for 40 days. The study design was determined as one control and two trial groups insert ignore into journalissuearticles values(each group with 2 parallels and each parallel with 4 rats);. The first group was given a basal ration and drinking water. The second group was given the basal ration and drinking water with 10 mg/kg resveratrol; and the third group was given the basal ration and drinking water 20 mg/kg resveratrol. In serum biochemistry parameters, significant decreases were observed in serum Aspartate aminotransferase insert ignore into journalissuearticles values(AST); enzyme activity, blood urea nitrogen insert ignore into journalissuearticles values(BUN);, albumin, total protein and globulin concentrations and increase in albumin/globulin ratio in groups given resveratrol insert ignore into journalissuearticles values(p<0.05);. Regardless of the dose, an increase in the concentration of glutathione insert ignore into journalissuearticles values(GSH); from the antioxidant parameters was observed in the liver; In the kidney, an increase was observed in the Res10 group. In addition, a decrease in muscle superoxide dismutase insert ignore into journalissuearticles values(SOD); activity and an increase in muscle and kidney catalase insert ignore into journalissuearticles values(CAT); activity were observed. A decrease was observed in malondialdehyde insert ignore into journalissuearticles values(MDA); concentrations, which is a parameter of lipid peroxidation in the kidney. As a result, it was determined in the present study that resveratrol has antioxidant effects regardless of the way of use, and it was concluded that this additive can be used for various purposes.
Keywords : Antioxidant, serum biochemistry, resveratrol, rat, water

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