THE EFFECTS OF CANCER’S METASTATIC STATUS AND CHEMOTHERAPY ON TOTALLY IMPLANTABLE VENOUS ACCESS PORT PATENCY AND PORT-RELATED VENOUS THROMBOEMBOLIC EVENTS

Authors : Serkan YAZMAN, Burak Can DEPBOYLU, Bengu DEPBOYLU, Emine DEPBOYLU, Buğra HARMANDAR

Pages : 104-109

Doi:10.52831/kjhs.1272466

View : 63 | Download : 44

Publication Date : 2023-08-31

Article Type : Research Paper

Abstract :Objective: Totally implantable venous access port insert ignore into journalissuearticles values(TIVAP); is of great importance as a vascular access route in the treatment of cancer patients. In this study, we retrospectively researched the effects of cancer types, metastases, chemotherapeutic drugs, and intervention sites on port patency and TIVAP-related venous thromboembolism insert ignore into journalissuearticles values(VTE);. Method: Demographics, cancer types, metastases, vascular access sites, chemotherapy drugs, TIVAP patency and TIVAP related complications were evaluated in 297 patients who had TIVAP implanted and 37 patients who underwent removal in our clinic between 2017-2021. Results: TIVAP implanted 297 patients were followed-up for a mean 17.7±16.6 months. TIVAPs were removed in 37 patients due to infection 14 insert ignore into journalissuearticles values(4.7%);, occlusion 8 insert ignore into journalissuearticles values(2.7%);, VTE 9 insert ignore into journalissuearticles values(3%);, malposition 1 insert ignore into journalissuearticles values(0.3%);, and treatment completion 10 insert ignore into journalissuearticles values(3.3%);. TIVAPs of 270 insert ignore into journalissuearticles values(90.9%); patients were found to be usable for an average of 18.5±17.1 months. Complications of VTE, occlusion, infection and malposition developed in a total of 71 insert ignore into journalissuearticles values(23.9%); patients. In the comparison of develepment of these complications according to the presence of metastasis in patients, it was found to be that they were significantly higher in metastatic patients insert ignore into journalissuearticles values(47-27.9%/24-18.6%, p<0.05);. There was a significant positive correlation between taxanes, methotrexate, etoposide and vinorelbine and the rate of VTE development compared to other chemotherapy drugsinsert ignore into journalissuearticles values(p<0.05);. The rate of TIVAP associated VTE was found to be significantly higher in elderly patients, patients with metastatic cancer and patients with lung cancer insert ignore into journalissuearticles values(p<0.05);. No significant difference was present in TIVAP patency, complications and TIVAP-related VTE, in terms of venous access site and side. Conclusion: Primary cancer, metastases, and chemotherapy are important factors for the development of systemic or TIVAP-related VTE. More multicenter studies are needed for the prevention and treatment of VTE in certain types of cancer and chemotherapy regimens that increase the risk of TIVAP-associated VTE.
Keywords : Tamamen İmplante Edilebilir Venöz Erişim Portu, Venöz Tromboembolizm, Kanser

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