Impact of Disulfide/Thiol Redox Couple on Pulse Wave Velocity in Patients with Normal Coronary Angiography

Authors : Selahattin AKYOL, Hazar HARBALIOĞLU, Mustafa GÜR, Özcan EREL, Hakim ÇELİK

Pages : 76-82

View : 17 | Download : 46

Publication Date : 2023-07-12

Article Type : Research Paper

Abstract :Introduction: The oxidized thiol/disulfide couple has been investigated and reported as a potential risk factor for cardiovascular diseases. Additionally, an increased pulse wave velocity has been identified as a predictor of cardiovascular events. Patients and Methods: 262 patients were included in our study. Native and total thiol levels, total disulfide levels, disulfide per total thiol ratios, native thiol per total thiol ratios, and disulfide per native thiol level ratios were calculated. Results: Patients were divided into Pulse Wave Velocity insert ignore into journalissuearticles values(PWV); low and PWV high groups. Native and total thiol levels were higher in PWV low group compared to PWV high group insert ignore into journalissuearticles values(p< 0.001 for both);. The median disulfide value was higher in PWV high group insert ignore into journalissuearticles values(p= 0.002);. Disulfide per native thiol and disulfide per total thiol ratio values were higher in PWV high group insert ignore into journalissuearticles values(p< 0.001);. Native thiol per total thiol ratios were higher in the PWV-low group insert ignore into journalissuearticles values(p< 0.001);. Conclusion: The disulfide/native thiol pathway may be an indicator for predicting future atherosclerotic cardiovascular events.
Keywords : Antioxidant, thiol, antioxidants