Effect of endothelıum on the repetıtıve concentratıon response curves to norepınephrıne ın rabbıt aorta

Authors : Ş OKTAY

Pages : 13-15

View : 10 | Download : 8

Publication Date : 1988-01-01

Article Type : Research Paper

Abstract :Endothelial cells release a relaxant factor, endothe- lum derived relaxing factor insert ignore into journalissuearticles values(EDRF);, and mediate relaxation of vascular smooth muscle induced by various agonists. On the other hand, removal of endothelium potentiates vasoconstrictor effect of norepinephrine insert ignore into journalissuearticles values(NE);. In the present study, it is shown that removal of the endothelium of isolated rabbit thoracic aortic strips, causes a significant increase in the slopes of the concentration-response curves to NE obtained repetitively after the control curve. An earlier desensitization was observed in rubbed preparations when compared with unrubbed strips. These findings suggest that removal of endothelium alters the characteristics of the concentration-response curves to NE and this may cause wrong interpretations if endothelium was not kept intact.
Keywords : Rabbit thoracic aorta, Norepinephrine, Endothelium