Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis

Authors : S ARBAK

Pages : 141-148

View : 13 | Download : 11

Publication Date : 1991-12-01

Article Type : Research Paper

Abstract :Studies have shown that prostaglandin E2 insert ignore into journalissuearticles values(PG E2); can prevent liver necrosis due to several agents. Dimethyl sulfoxide insert ignore into journalissuearticles values(DMSO); is also known with its cytoprotective efficiency. To determine the degree of cytoprotective effectivenesses of these two agents, 20 female rats were divided into 5 groups. Livers of rats treated only with carbon tetrachloride showed severe necrosis. In groups pretreated with prostaglandin E2 and dimethyl sulfoxide, degree of necrosis was very low. Especially prostaglandin E2 could perform this cytoprotection very well. It is concluded that these two cytoprotective agents could prevent carbon tetrachloride-induced liver cell necrosis in the rats at different degrees.
Keywords : Carbon tetrachloride, prostaglandin E2, dimethyl sulfoxide, cytoprotection