Effect of nimodipine on vasospasm after experimental subarachnoid hemorrhage in rats

Authors : F TURAN, M ZARİFOĞLU, A EVREN, E OĞUL, İ BORA

Pages : 145-148

View : 38 | Download : 8

Publication Date : 1992-12-01

Article Type : Research Paper

Abstract :This experimental vasospasm model was made by giving the autologous blood into the cisterna magna. Later Nimodipine insert ignore into journalissuearticles values(ND); was administered by intracisternal or subcutaneous insert ignore into journalissuearticles values(s.c.); way in defined times. After that, in the light microscopic examination, the wall thickness insert ignore into journalissuearticles values(W);, lumen insert ignore into journalissuearticles values(L); and diameter insert ignore into journalissuearticles values(D); of basilar artery were measured and diameter/wall thickness insert ignore into journalissuearticles values(D/W);, diameter/lumen insert ignore into journalissuearticles values(D/L); ratios were studied and compared with control group with SAH. In the first group, intracisternal ND was administered immediately after experimental SAH, ND doses were 10 pg/kg insert ignore into journalissuearticles values(n: 5);, 20 pg/kg insert ignore into journalissuearticles values(n:4);, and 50 pg/kg insert ignore into journalissuearticles values(n:5);. There was no significant difference in the measurements between study group and control insert ignore into journalissuearticles values(n: 9);. In the second group which received s.c. 100 pg/kg t.i.d. for 72 hours, the wall thickness significantly decreased when compared to control group insert ignore into journalissuearticles values(p<0.01); but the other parameters did not change. The double-hemorrhage group which received same dose insert ignore into journalissuearticles values(100 pg/kg); of ND showed significant increase in the D/W ratio when compared to matching control group insert ignore into journalissuearticles values(p<0.01);. But there was no change in other parameters. Electron microscopy was made only in rats with SAH taking 100 pg/kg t.i.d. ND for 72 hours. Ultrastructural changes were endothelial changes, subendothelial blebs, corrugation of lamina elastica interna, endothelial denudation and intracytoplasmic vacuoles in both control group with SAH and ND receiving ones. Intracytoplasmic smooth-muscle vacuoles were less prominent in the rats receiving ND. These findings may indicate that ND shows its effectiveness on experimental vasospasm by decreasing the wall thickness and preventing some morphologic and ultrastructural changes.
Keywords : Nimodipine, Experimental Subarachnoid Hemorrhage, Vasospasm, Basilar artery

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