Nimodipine has no effects on ceftriaxone - induced epileptogenic focus in rabbits

Authors : F TURAN, S SADİKOGLU, A DALGİÇ, î BORA, M ZARİFOGLU, N BALKIR

Pages : 6-10

View : 14 | Download : 11

Publication Date : 1995-01-01

Article Type : Research Paper

Abstract :In this study antiepileptic effects of nimodipine insert ignore into journalissuearticles values(ND); on ceftriaxone - induced epileptogenic focus in twenty rabbits were analysed. After base - line EEG was recorded 3% ceftriaxone was administered topically under dura mater of left sensori-motor area. EEG recording was made at least for twenty minutes. ND was given intravenously in doses of 0.1 mg/kg for three minutes and EEG recording was continued for thirty minutes. The parameters used in EEG analysis were the number of spikes, spike and wave bursts per second and EEG scores evaluated in both the ipsilateral and contralateral focus. The number of spikes, spike and wave bursts per second decreased after ND in four rabbits insert ignore into journalissuearticles values(20%);, but increased in four rabbits insert ignore into journalissuearticles values(20%);. No changes were observed in the others insert ignore into journalissuearticles values(60%);. The EEG scores showed no difference before and after ND. In the second step, diazepam was administered intravenously in dose of 0.5 mg/kg to twelve rabbits receiving ND. EEG findings and foci absolutely disappeared in four rabbits insert ignore into journalissuearticles values(33.3%); but in the others insert ignore into journalissuearticles values(66.7%); showed general depressing activity with minimal epileptic activity. The EEG scores of diazepam receiving group after ND decreased significantly insert ignore into journalissuearticles values(p<0.01);. We conclude that ND is not effective on ceftriaxone - induced epileptogenic focus in rabbits.
Keywords : Nimodipine, Ca channel blocker, experimental focal epilepsy