Acute promyelocytic leukemia evolving from paroxysmal nocturnal hemoglobinuria: A rare occurrence

Authors : Rafet EREN, Tayfur TOPTAŞ, İşık Kaygusuz ATAGÜNDÜZ, Tülin Fıratlı TUĞLULAR

Pages : 114-116

Doi:10.5472/MMJcr.2902.02

View : 21 | Download : 10

Publication Date : 2016-04-01

Article Type : Research Paper

Abstract :A previously healthy 31-year-old female presenting with dyspnea, iron deficiency anemia, pancytopenia, splenomegaly, and abnormal coagulation tests was admitted to the hospital. Hematology consultation additionally revealed that 71% of cells were indicative of acute promyelocytic leukemia insert ignore into journalissuearticles values(APL); and the patient tested positive for a tinsert ignore into journalissuearticles values(15;17); translocation, confirming APL. All-trans retinoic acid insert ignore into journalissuearticles values(ATRA); therapy was initiated immediately, but the patient exhibited severe dyspnea. This subsequently resulted in circulatory and respiratory arrest, followed by death. Just after death, fluorescein-labelled proaerolysin insert ignore into journalissuearticles values(FLAER); revealed a paroxysmal nocturnal hemoglobinuria insert ignore into journalissuearticles values(PNH); monocyteclone of 82%, confirming the diagnosis of PNH. Leukemia can be derived from non-PNH clones in PNH patients. Catastrophic thromboembolic events that could not be controlled with aggressive anticoagulation in a profoundly thrombocytopenic patient without overt disseminated intravascular coagulation insert ignore into journalissuearticles values(DIC); may suggest co-existent PNH.Keywords: Leukemia, Promyelocytic, Acute, Hemoglobinuria, Paroxysmal
Keywords : Lösemi, Promyelositik, Akut, Hemoglobinuri, Proksismal