Hepatic veno-occlusive disease after bone marrow transplantation

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Marmara Medical Journal
Volume:9 Issue:2
Hepatic veno-occlusive disease after bone marrow transplantation

Hepatic veno-occlusive disease after bone marrow transplantation

Authors : C Canpolat, D Başdemir

Pages : 0-0

View : 45 | Download : 10

Publication Date : 1996-03-01

Article Type : Research Paper

Abstract :In the first few weeks after bone marrow transplantation, a clinical syndrome characterized by hepatomegaly, jaundice, and fluid retention develops in 10 to 70% of patients. This syndrome is due to damage to endothelial cells, sinusoids, and hepatocytes in zone 3 of thejiver acinus. The proximate cause of the damage is cytoreductive therapy. This syndrome, often called veno-occlusive disease of the liver, can vary in severity from mild reversible disease to fatal disease associated with multiorgan failure
Keywords : Hepatic veno occlusive disease, Bone marrow transplantation, Cytoreductive therapy

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