EFFECTS OF DEFIBROTIDE ON STRESS-INDUCED BLADDER MORPHOLOGY

Authors : Feriha Ercan, Tangül San, Safiye Çavdar, Oya Karabulut

Pages : 33-38

View : 14 | Download : 8

Publication Date : 2016-12-03

Article Type : Research Paper

Abstract :Objective: This study investigates the morphological effect of defibrotide on cold-immobilization stress- induced rat urinary bladder. Material and Methods: Wistar albino rats were used in this study. After the cold, immobilization stress following the 48 hours of fasting, defibrotide was applied either intraperitonally insert ignore into journalissuearticles values(16 mg/ml); or intravesically insert ignore into journalissuearticles values(1200pg/ml);. Urinary bladders were removed for light and electron microscopical investigations. Results: The stress group showed leukocyte infiltration and edema, further vacuoles in the cytoplasm of urothelial cells and loose tight junctions. Additionally, urothelial protrusions towards the lumen were observed. The defibrotide-applied groups displayed regular morphology both under light and electron microscopy level. Conclusion: These results showed that defibrotide reverse the stress induced morphological alterations. Although the biochemical effects of defibrotide is unknown, a possible explanation could be via modulation of calcium entry into the cells, and increase the permeability and regulation of inflammatory response and/or may have a role in the protection of urothelium by increasing the synthesis of prostaglandins and have a cytoprotective role in stress-induced bladder damage. Key Words: Defibrotide, cytoprotection, cold- immobilization stress, urinary bladder, ultrastructure
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