ENDOTHELIN-1 LEVELS IN CHILDHOOD LIVER DISEASE

Authors : Nafiye Urgancı, Fügen Çullu, Bayram Kıran, Tülay Erkan, Tufan Kutlu, Güngör Tümay, Gülşen Özbay

Pages : 161-168

View : 16 | Download : 6

Publication Date : 2016-12-03

Article Type : Research Paper

Abstract :Objective: An in-patient with portal hypertension PH was used in a trial conducted to determine the levels of vasoconstrictors endothelin-1 insert ignore into journalissuearticles values(ET- 1);, Atrial natriuretic peptid insert ignore into journalissuearticles values(ANP);, Angiotensin-ll, aldosterone and vasopressin, and to investigate the correlation between ET-1 and the other hormones. Methods: The trial included 40 patients with chronic active hepatitis B insert ignore into journalissuearticles values(CAH-B); insert ignore into journalissuearticles values( n=10);, cirrhosis with portal hypertension insert ignore into journalissuearticles values(PH ); insert ignore into journalissuearticles values(n=14);, cirrhosis insert ignore into journalissuearticles values(n=6); and extrahepatic PH insert ignore into journalissuearticles values(n=10);. The patients were followed up for one year in the pediatric clinic of the Cerrahpaşa School of Medicine in Istanbul, Turkey. Nineteen of them were female and 21 of them were male, with a mean age ± Standard deviation insert ignore into journalissuearticles values(sd); SD of 10.2 ± 6.2 years. The control group included 10 healthy children, all of whom were male with a mean age of 9.2 ± 6 years. Plasma ET-1, ANP, Angiotensin-ll, aldosterone and vasopressin levels were measured by radioimmunoassay insert ignore into journalissuearticles values(RIA); method in Istanbul University, Medical School, Experimental Research Institute insert ignore into journalissuearticles values(DETAM);. Results : Plasma ET-1 levels in chronic liver patients were higher than in the healthy control group according to One Way Analysis of Variance insert ignore into journalissuearticles values(ANOVA); insert ignore into journalissuearticles values(p=0.0001);. In chronic liver disease patients, there was a positive correlation between ET-1 and aldosterone, ANP and ADH respectively r=0.45 insert ignore into journalissuearticles values(p=0.003);, r=0.37 insert ignore into journalissuearticles values(p=0.003);, r=0.40 insert ignore into journalissuearticles values(p=0.0001 );. In the same group, there was No correlation between ET-1 and angiotensin-ll insert ignore into journalissuearticles values(r=0.22, p=0.07);. Conclusion: In conclusion, we found that ET-1 levels were higher in group I and IV than in the control group. Plasma ET-1 levels increase in patients diagnosed as having chronic liver disease with an undefined mechanism. This could be explained by either an increase in production or decrease in metabolic clearances or probably by both of these mechanisms. Key Words: Chronic liver disease, Endothelin-1, Childhood
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