THE RELATIONSHIP BETWEEN MATERNAL SERUM a- FETOPROTEIN AND UTERINE ARTERY DOPPLER FINDINGS AT 20-24 WEEKS` GESTATION FOR PREDICTION OF PREECLAMPSIA AND INTRAUTERINE GROWTH RETARDATION

Authors : Seyfettin Uludağ, Rıza Madazlı, Ali Benian, Vildan Ocak, Selçuk Erez

Pages : 169-174

View : 8 | Download : 12

Publication Date : 2016-12-03

Article Type : Research Paper

Abstract :Objective: To estimate the relationship between maternal serum a- fetoprotein insert ignore into journalissuearticles values(MSAFP); levels and uterine artery Doppler findings at 20th week of pregnancy for prediction of preeclampsia and intrauterine growth retardation insert ignore into journalissuearticles values(IUGR);. Methods: Eighty pregnant women were followed as a study group prospectively. MSAFP levels at the 15-18th week of gestation and bilateral uterine artery Doppler findings at the 20th week of gestation were obtained. Results: Bilateral early diastolic notch of the uterine artery was detected in 17 cases insert ignore into journalissuearticles values(21,75%); at the 20th week of gestation. In 9 of them early diastolic notch was persistent at the 24th week while in 8 cases, it had disappeared. Uterine artery diastolic notch was found to be a significant predictive factor for preeclampsia, as well as for IUGR insert ignore into journalissuearticles values(p< 0.001, OR: 69.74; p<0.02, OR: 10.11, respectively);. MSAFP levels of 17 cases that showed early diastolic notch in uterine artery Doppler were significantly higher than in the notch negative cases insert ignore into journalissuearticles values(p<0.05);. The levels of MSAFP in 9 cases which demonstrated the persistence of diastolic notch, were significantly higher than the 8 cases where the notch had disappeared, at the 24th week of gestation insert ignore into journalissuearticles values(p<0.05);. Conclusion: Our findings suggest that abnormal uterine artery Doppler findings at 20th week of gestation correlate with elevated MSAFP levels, and bilateral diastolic notch in uterine artery at 20 weeks’ gestation together with elevated MSAFP, is associated with poor obstetric outcome. Key Words: IUGR, Preeclampsia, MSAFP, Diastolic notch
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