THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS

Authors : Esin KOTİLOĞLU, Handan KAYA, Saime SEZGİN, Gülsün EKİCİOĞLU

Pages : 33-38

View : 16 | Download : 9

Publication Date : 2016-12-03

Article Type : Research Paper

Abstract :Objective: We investigated the expression of basic Fibroblast Growth Factor insert ignore into journalissuearticles values(bFGF); and c-kit proto-oncogene in progression to malignancy and métastasés of melanocytic lesions. Methods: Immunohistochemical detection of bFGF and c-kit receptors were performed by peroxidase- antiperoxidase insert ignore into journalissuearticles values(PAP); technique on compound nevi, vertical growth phase malignant melanoma and metastatic malignant melanoma in 12, 12 and 15 cases respectively. Clinicopathological correlations were analysed by Paerson’s Chi-Square, Student’s T-Test and One Way Anova test. Results: bFGF receptor immunoreactivity rates were 83.3%, 83.3% and 80 % in compound nevi, primary MMs and metastatic MMs respectively, c-kit immunoreactivity was absent in nevus cells, but faintly present in 16.6 % insert ignore into journalissuearticles values(2 cases); of MM cells. Conclusion: The results of our study suggest that loss of c-kit expression is more important in dermal penetration than métastasés in melanomas.However, bFGF is not shown to be a prognostic factor for MMs. Key Words: c-kit, bFGF, Melanocytic nevi, Malignant melanoma, Metastatic melanoma
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