COMPARISON OF THE EFFICACY AND SAFETY OF ISEPAMICIN AND AMIKACIN IN THE TREATMENT OF URINARY TRACT INFECTION IN CHILDREN

Authors : Arif BAHAR, Ferhan KARADEMİR, Tolga UNSUR, Mustafa ÖZYURT, İsmail GÖÇMEN

Pages : 107-112

View : 59 | Download : 8

Publication Date : 2016-12-03

Article Type : Research Paper

Abstract :Objective: In this study we aimed to compare the efficacy and safety of isepamicin versus amikacin at a dose of 7.5 mg/kg of body weight twice daily for 10-14 days in children with urinary tract infections insert ignore into journalissuearticles values(UTI);. Methods: One hundred and seventeen patients with urinary tract infection were enrolled in this study. Patients were randomized to treatment with isepamicin or amikacin in a 1:2 ratio. Urinary tract infections were treated with isepamicin insert ignore into journalissuearticles values(n=42);, or amikacin insert ignore into journalissuearticles values(n=75);. Results: The most commonly isolated pathogens were Escherichia coli, Staphylococcus spp., Klebsiella pneumonia, Proteus mirabilis and Enterobacter spp. The overall clinical response rate at the end of treatment was excellent in all treatment groups insert ignore into journalissuearticles values(93.0/93.4% cured); with no significant differences between isepamicin and amikacin in patients with infections. None of the patients had a life-threatening or severe adverse event that required discontinuation of the drug. Conclusion: Isepamicin was shown to be as effective and as well tolerated as amikacin in the treatment of urinary tract infections in pediatric patients.
Keywords : Isepamicin, Amikacin, Aminoglycoside, Pediatrics

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