Early-onset neurolupus: A challenge for pediatricians

Authors : Safa BARIŞ, Elif KARAKOÇAYDINER, Ahmet ÖZEN, Melissa KAÇMAZ, Medya NAMAR, Nurdan YILDIZ, Dilşat TÜRKDOĞAN, İşıl BARLAN
Pages : 105-108
Doi:10.5472/MMJcr.2802.08
View : 52 | Download : 15
Publication Date : 2015-09-14
Article Type : Other Papers
Abstract :Systemic lupus erythematosus insert ignore into journalissuearticles values(SLE); is a challenge for pediatricians due to the heterogeneity of its clinical manifestations and the rarity of the disorder in this age group. Neuropsychiatric SLE insert ignore into journalissuearticles values(NPSLE); was defined especially in adult patients and the clinical course of this manifestation is still not clearly defined in the pediatric age group. We, here report a five-year old girl presenting with extensive maculopapular skin lesions, oral ulcers and neuropsychiatric symptoms. She had elevated titers of anti-nuclear antibody insert ignore into journalissuearticles values(ANA);, Anti-ds-DNA, anti-histone antibodies and complement levels. Serum coxsackie and cytomegalovirus insert ignore into journalissuearticles values(CMV); IgM tests were positive, as well. Magnetic resonance imaging insert ignore into journalissuearticles values(MRI); of the brain demonstrated extended cerebral and cerebellar atrophy. Pediatricians should be attentive to the possibility of neurolupus for patients with neurological problems despite a young age at presentation. Appropriate therapy is a challenging task. Keywords: Neuropsychiatric lupus , Pediatrics , CMV , Coxsackie
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