The role of myocardial performance index and Nt-proBNP levels as a marker of heart dysfunction in nonalcoholic cirrhotic patients

Authors : Sena TOKAY TARHAN, Feruze YILMAZ ENÇ, Fatih EREN, Ali Serdar FAK, Osman ÖZDOĞAN

Pages : 10-16

Doi:10.5472/marumj.1056204

View : 15 | Download : 9

Publication Date : 2022-01-31

Article Type : Research Paper

Abstract :Objective: Cardiac dysfunction has been reported in both cirrhotic and alcoholic patients. Our aim was to determine the relation of serum N-terminal pro-B-type natriuretic peptide insert ignore into journalissuearticles values(Nt-proBNP); levels to myocardial performance index insert ignore into journalissuearticles values(MPI); and disease severity in nonalcoholic cirrhotic patients. Patients and Methods: In this prospective study including 25 cirrhotic patients and 27 healthy controls, MPI was assessed by pulsed-wave tissue Doppler imaging insert ignore into journalissuearticles values(PW-TDI);. The disease severity was determined by Child–Turcotte–Pugh insert ignore into journalissuearticles values(CTP ); and model for end-stage liver disease insert ignore into journalissuearticles values(MELD); scores. Results: There were no statistically significant differences in MPI levels between patients and controls insert ignore into journalissuearticles values(p< 0.246);. Nt-proBNP levels insert ignore into journalissuearticles values(p< 0.0003);, cardiac output insert ignore into journalissuearticles values(CO); insert ignore into journalissuearticles values(p< 0.0002);, left ventricular end-systolic insert ignore into journalissuearticles values(LVES); volume insert ignore into journalissuearticles values(p< 0.031); and QT interval insert ignore into journalissuearticles values(p< 0.0001); increased. Left ventricular systolic function was normal in all cirrhotic patients when compared to controls. Nt-proBNP levels were positively correlated with MELD scores insert ignore into journalissuearticles values(p< 0.0001, r= 0.59);, QT duration insert ignore into journalissuearticles values(p< 0.0001, r= 0.59);, CO insert ignore into journalissuearticles values(p= 0,001, r= 0.44);, right atrial insert ignore into journalissuearticles values(RA); area insert ignore into journalissuearticles values(p= 0.026, r= 0.31); and negatively correlated with diastolic BP insert ignore into journalissuearticles values(p= 0.015, r= -0.34);. Conclusion: We conclude that in nonalcoholic cirrhotic patients, left ventricular MPI and systolic function were normal. Nt-proBNP levels were correlated with the disease severity and hyperdynamic circulation.
Keywords : Cirrhosis, Heart failure, Nt proBNP, Echocardiography