The effect of preemptive use of plerixafor on stem cell mobilization in patients with lymphoma and multiple myeloma

Authors : Ayse UYSAL, Mehmet Ali ERKURT, Irfan KURU, Emin KAYA, Ilhami BERBER, Ahmet SARICI, Soykan BICIM, Ahmet KAYA, Emine HIDAYET
Pages : 65-71
Doi:10.5472/marumj.1244684
View : 39 | Download : 5
Publication Date : 2023-01-31
Article Type : Research Paper
Abstract :ABSTRACT Objective: The aim of this study is to investigate the effect of the preemptive use of plerixafor in patients with lymphoma and multiple myeloma which was administered as a preemptive single dose to the patients who were determined to have a CD34+ cell count of <15/ μL in the peripheral blood insert ignore into journalissuearticles values(PB); on the 4th day of mobilization. Patients and Methods: Thirty-five patients who were administered plerixafor on the 4th day after granulocyte colony-stimulating factor insert ignore into journalissuearticles values(G-CSF); alone for stem cell mobilization between January 2020 and November 2021 were included. CD34+ stem cell counts in PB before and after plerixafor, the amount of CD34+ stem cells collected, and the outcome of transplantation was examined. Results: The median CD34+ cell count in PB on the 4th day was 5.2/μL insert ignore into journalissuearticles values(0.1-13.4);, which was determined to increase 206.6-fold insert ignore into journalissuearticles values(31.57- 49347); to 924.80 /μL insert ignore into journalissuearticles values(295.00-5056); following the administration of plerixafor on the 5th day insert ignore into journalissuearticles values(Z=-5.160; r= – 872.2; p<0.0001);. The number of apheresis sessions was 1 in all patients. The median collected CD34+ cell count was 5.90x106/kg insert ignore into journalissuearticles values(2.70x106-14.4x106);. Conclusion: The use of preemptive plerixafor shows that it is an effective mobilization method by increasing the rate of stem cell collection at an effective dose and reducing the mobilization time/apheresis sessions.
Keywords : Apheresis, Stem cell, Mobilization, Plerixafor, Preemptive

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