Classification of Prostate Cancer and Determination of Related Factors with Different Artificial Neural Network

Authors : İpek BALIKÇI ÇİÇEK, Zeynep KÜÇÜKAKÇALI

Pages : 325-332

Doi:10.19127/mbsjohs.798559

View : 26 | Download : 20

Publication Date : 2020-12-31

Article Type : Research Paper

Abstract :Objective: In this study, it is aimed to classify prostate cancer, compare the predictions of these two models and determine the factors associated with the disease by applying Multilayer Perceptron Neural Network insert ignore into journalissuearticles values(MLPNN); and Radial-Based Function Neural Network insert ignore into journalissuearticles values(RBFNN); methods on the open access Prostate cancer dataset. Methods: In this study, the dataset named `Prostate Cancer Data Set` was used by obtaining from https://www.kaggle.com/sajidsaifi/prostate-cancer address. To classify prostate cancer, MLPNN and RBFNN methods, which are artificial neural network models, is used. The classification performance of the models was evaluated with the sensitivity, specificity, accuracy, negative predictive value and positive predictive value, which are among the classification performance metrics. Prostate cancer related factors were estimated by using MLPNN and RBFNN models. Results: With the applied MLPNN model, performance metric values were obtained as AUC 0.937, Sensitivity 100%, accuracy 92.5%, Selectivity 84.6%, Positive predictive value 87.5% and Negative predictive value 100%. With the RBFNN model, the performance metric values were obtained as AUC 0.921, Sensitivity 83.3%, accuracy 86.6%, Selectivity 91.6%, Positive predictive value 93.7% and Negative predictive value 78.5%. When the effects of variables in the dataset in this study on prostate cancer are examined; The three most important variables for the MLPNN model were obtained as perimeter, area and compactness, respectively. For the RBFNN model, the three most important variables were obtained as perimeter, area and compactness, respectively. Conclusion: It was seen that MLPNN and RBFNN models used in this study gave successful predictions in the classification of prostate cancer. In addition, estimating the significance values of factors associated with the disease with these classification models made it different from similar studies with the same dataset.
Keywords : Prostate cancer, Multilayer perceptron neural network, Radial based function neural network, Classification