Assessment of oxidative stress with thiol disulfide homeostasis and ischemia-modifıed albumin level in acute urticaria

Authors : İsmail Erkan AYDIN, Şeyda Tuba SAVRUN, Atakan SAVRUN, Sevda ÖNDER, Salim NEŞELİOĞLU, Özcan EREL, Yeliz KAŞKO ARICI

Pages : 115-121

Doi:10.19127/mbsjohs.908621

View : 27 | Download : 12

Publication Date : 2021-04-30

Article Type : Research Paper

Abstract :Objective: There is no study in the literature investigating ischemia-modified albumin insert ignore into journalissuearticles values(IMA); values and thiol disulfide homeostasis insert ignore into journalissuearticles values(TDH); parameters in acute urticaria patients. This study aimed assessment of TDH parameters and IMA in acute urticaria patients. Methods: The study included a total of 68 cases, with 35 acute urticaria patients and 33 healthy volunteers. Patients who presented to Ordu University Hospital and were diagnosed with acute urticaria between January 2019 and June 2019 and healthy individuals as the control group were included in the study. Serum albumin, IMA, native thiol, total thiol, and disulfide thiol levels were measured, and the results were compared between the groups. Results: IMA values of 0.93±0.09 in the study group were significantly high compared to 0.8±0.10 in the control group insert ignore into journalissuearticles values(p<0.01);. Native thiol insert ignore into journalissuearticles values(SH); level was 353.66±87.5 in the study group, 393.62±47.7 in the control group insert ignore into journalissuearticles values(p:0.022);, and total thiol insert ignore into journalissuearticles values(TSH); level was 385.46±86.6 in the study group and 433.53±56.06 in the control group insert ignore into journalissuearticles values(p:0.008);. In the patient group there was a significant negative correlation between SH levels and IMA levels insert ignore into journalissuearticles values(r=-0.626, p<0.001);. Conclusion: In acute urticaria, IMA increases while SH and TSH levels reduce. However, TDH does not change. The lack of change in the balance may be explained by acute urticaria being an acute event and not being a chronic inflammatory process.
Keywords : acute urticaria, thiol disulfide, ischemia modified albumin, oxidative stress