Relationship of Thyroid Function with Metabolic Parameters in Euthyroid Adults

Authors : Gülsen ŞENER

Pages : 169-180

Doi:10.19127/mbsjohs.1215262

View : 22 | Download : 10

Publication Date : 2023-02-28

Article Type : Research Paper

Abstract :Objective: Thyroid hormones have a significant effect on carbohydrate, lipid metabolism disorders, and insulin resistance insert ignore into journalissuearticles values(HOMA-IR); development. Vitamin D insert ignore into journalissuearticles values(25insert ignore into journalissuearticles values(OH);D); has been shown also can affect not only the musculoskeletal system, but also almost all tissues in the body, including the thyroid in recent years. In the study, we aim of this study is to investigate the relationship between the levels of thyroid-stimulating hormone insert ignore into journalissuearticles values(TSH); within the reference range and metabolic parameters in adults. Methods: 561 adult outpatients were divided into 2 groups low normal range insert ignore into journalissuearticles values(0.27-2.5 mIU/mL); and high normal range insert ignore into journalissuearticles values(2.5-4.2 mIU/mL); according to TSH, and HOMA-IR, 25insert ignore into journalissuearticles values(OH);D, and lipid levels were compared. Results: A statistically significant positive correlation was found between TSH and HOMA-IR in both the low normal range group insert ignore into journalissuearticles values(r = 0.123, p = 0.041); and the high normal range group insert ignore into journalissuearticles values(r = 0.196, p = 0.001);. In the high normal range group, the relationship between TSH with vitamin D insert ignore into journalissuearticles values(r =-0.200, p =0.003);, cholesterol insert ignore into journalissuearticles values(r =0.143, p =0.024);, LDL cholesterol insert ignore into journalissuearticles values(r =0.154, p =0.018);, non-HDL cholesterol insert ignore into journalissuearticles values(r = 0.134, p = 0.035); levels was statistically significant. Conclusion: Our study shows that high normal TSH levels in euthyroid adults are related to higher insulin resistance and lower 25insert ignore into journalissuearticles values(OH);D levels, and this interaction is a major contributor to dyslipidemia. Thyroid hormones explain the metabolic disorder in the early stages of T2DM. Therefore, we believe that screening TSH levels and determining the optimal TSH target will be beneficial.
Keywords : Euthyroidism, insulin resistance, lipid profile, vitamin D