SOME NOVEL SCHIFF BASE DERIVATIVES AS PROMISING CHOLINESTERASE INHIBITORS WITH ANTIOXIDANT ACTIVITY AGAINST ALZHEIMER’S DISEASE: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION

Authors : Ercan ÇINAR, Mehmet BOĞA, Giray TOPAL, Reşit ÇAKMAK

Pages : 138-146

Doi:10.51477/mejs.1204413

View : 61 | Download : 9

Publication Date : 2022-12-31

Article Type : Research Paper

Abstract :In this manuscript, five novel Schiff base derivatives containing a pyrazolone ring and a sulfonate moiety insert ignore into journalissuearticles values(6-10); except for 9 were designed, obtained for the first time and characterized by three spectroscopic techniques. The inhibition performances of these moleucles synthesized in two steps against cholinesterases, namely acetylcholinesterase insert ignore into journalissuearticles values(AChE); and butyrylcholinesterase insert ignore into journalissuearticles values(BChE); were evaluated. By DPPH and ABTS assays, antioxidant activities of these molecules were also examined. In AChE assay, compound 6 insert ignore into journalissuearticles values(95.87±1.59 % inhibition); inhibited this enzyme better than galanthamine insert ignore into journalissuearticles values(76.98±0.42 % inhibition);. In BChE assay, compound 10 with 87.92±1.08% inhibition value in the series indicated the highest activity compared to galanthamine insert ignore into journalissuearticles values(76.30±0.28 % inhibition);. In ABTS radical scavenging assay, compounds 7, 8 and 9 except for 6 and 10 indicated higher antioxidant activities compared to butylated hydroxytoluene insert ignore into journalissuearticles values(BHT);. It is believed that these results may contribute to the design and synthesis of novel antioxidant agents, AChE and BChE inhibitors.
Keywords : Schiff base, Enzyme inhibitor, Antioxidant agent, Alzheimers disease

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