IDENTIFICATION OF CHEMICAL CONSTITUENTS AND EVALUATION OF BIOLOGICAL ACTIVITIES OF Piper cubeba EXTRACTS

Authors : Bihter Şahin, Emine Baştürk

Pages : 127-134

Doi:10.22531/muglajsci.1782879

View : 25 | Download : 111

Publication Date : 2025-12-31

Article Type : Research Paper

Abstract :Piper cubeba L., commonly known as cubeb, is a medicinal plant known for its essential oil and phenolic compounds with various biological activities. In this study, fruits of P. cubeba collected from Gaziantep were analyzed for their chemical composition and bioactivity. The essential oil, obtained via hexane extraction and analyzed by GC-MS, contained 49 compounds, with Eudesma-3,7(11)-diene (31.00%) as the major component, followed by cubenol, β-cubebene, and others. Sequential solvent extraction (acetone, ethyl acetate, methanol, and water) was performed, and the phenolic profiles of the extracts were determined using HPLC-DAD. The major phenolics identified included 1,4-dichlorobenzene, curcumin, cynarin, and rutin. Antioxidant activities were evaluated using DPPH, ABTS, CUPRAC, and β-carotene-linoleic acid assays. The water extract (PC4) showed the strongest antioxidant capacity among all extracts. Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition assays revealed that the acetone extract (PC1) exhibited the highest enzyme inhibitory activity. This comprehensive study provides new insights into the chemical composition and biological potential of P. cubeba fruits collected from Turkey.
Keywords : Piper cubeba, Fenolik bileşikler, Kimyasal içerik, Enzim inhibisyon aktivite

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