Synthesis, Characterization, Antimalarial and Antimicrobial activities of Mixed Ibuprofen-Pyrimethamine M(II) Complexes [M = Cd, Co, Zn, Mn]

Authors : Mercy BAMİGBOYE, İkechukwu EJİDİKE

Pages : 30-37

Doi:10.38061/idunas.629389

View : 105 | Download : 11

Publication Date : 2019-12-31

Article Type : Research Paper

Abstract :Mixed complexes of Ibuprofen-Pyrimethamine were synthesized using Cdinsert ignore into journalissuearticles values(II); Coinsert ignore into journalissuearticles values(II);, Zninsert ignore into journalissuearticles values(II); and Mninsert ignore into journalissuearticles values(II);. The mixed complexes were characterized based on some physico-chemical and spectroscopic techniques such as infrared, elemental analysis, conductivity measurements, and magnetic moment. Based on the results obtained, the complexes were formulated as [Minsert ignore into journalissuearticles values(L 1 );insert ignore into journalissuearticles values(L 2 );]Cl 2 , where M = metal ion, L 1 = Pyrimethamine, L 2 = Ibuprofen);. The complexes were found to be non-electrolytes. The ligands act as bidentate towards the central metal ions with deprotonation occurring at the carboxylic group. The complexes were also analyzed by conductometric titration. Antimicrobial screening against the selected organisms: Escherichia coli , Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus substilis, Bacillus megaterium and Serratia marcescens for t he complexes alongside the free ligands was investigated . Antimalarial study was investigated for the compounds against Plasmodium berhei insert ignore into journalissuearticles values(NK 65 strain);. It was observed that the complexes showed significant potentials against the studied organisms.
Keywords : Ibuprofen, Antimicrobial, Pyrimethamine, Metal Complexes

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