Cathodal tDCS and HD-tDCS neuromodulation techniques in the treatment of patients with Drug resistant epilepsy

Authors : Marya Alhajmohammadothman, Benjamin Sogodam Atadana, Hilal Göktaş

Pages : 81-100

Doi:10.38061/idunas.1483732

View : 57 | Download : 93

Publication Date : 2025-12-31

Article Type : Review Paper

Abstract :Cathodal transcranial Direct Current Stimulation (ctDCS) is a safe non-invasive neuromodulation method that has been examined for the management of epilepsy over the past three decades to decrease seizure frequency. The advanced version of transcranial Direct Current Stimulation (tDCS), High-Definition transcranial Direct Current Stimulation (HD-tDCS) has been developed to provide increased focus because of its focal effect and diminshed neuromodulatory effects beyond the epileptogenic area of interest hence it is preferred over traditional tDCS. Purpose: Scientists and researchers performing animal and human clinical research and clinical trials suggest that ctDCS or HD-tDCS may suppress seizures for patients with drug-resistant focal epilepsy. The purpose of this review paper is to analyze and compile clinical studies and research articles to gain a deeper understanding of the capability of HD-tDCS in managing seziures for patients with drug-resistant epilepsy. Conclusion: Application of optimized HD-tDCS (HD-tDCS) for majority of the cases can effectively decrease seizure frequency for patients with drug-resistant focal epilepsy (DRFE). Some patients, however had increased seizure frequency due to unknown reasons that ought to be researched.
Keywords : transcranial Direct Current Stimulation, drug-resistant epilepsy, brain stimulation, patient personalization treatment

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