Evaluation of Serum, Saliva and GCF Visfatin Levels in Chronic Periodontitis Patients with Uncontrolled /Controlled Type2 Diabetes Mellitus

Authors : Mustafa Cihan YAVUZ, Cenk Fatih ÇANAKÇI

Pages : 817-823

Doi:10.15311/selcukdentj.1009374

View : 22 | Download : 8

Publication Date : 2021-12-31

Article Type : Research Paper

Abstract :Background: Visfatin is a multifaceted protein that plays an important role in diabetes insert ignore into journalissuearticles values(DM); and periodontitis insert ignore into journalissuearticles values(CP);. It has been known that during inflammation, the production of IL-1b, TNF-a can be induced by visfatin. Therefore, visfatin is an important mediator for both diseases. The aim of this study is to investigation of visfatin levels in serum, saliva and GCF samples of non-diabetic periodontitis patients and controlled and uncontrolled diabetic periodontitis patients, and evaluation of the relationship with clinical and biochemical parameters of periodontitis Methods: Study protocol, 5 groups which each one were consisted of 15 subjects were planned: periodontally healthy patients with systemically healthy insert ignore into journalissuearticles values(DM-P-);; patients with systemically healthy and CP insert ignore into journalissuearticles values(DM-P+);, periodontally healthy patients with diabetes insert ignore into journalissuearticles values(DM+P-);, patients with diabetes and CP insert ignore into journalissuearticles values(DM+P+);, patients with uncontrolled diabetes and CP insert ignore into journalissuearticles values(uDM+P);. Serum, saliva and GCF samples were obtained and, levels of visfatin, TNF-α and IL-1β were determined by ELISA. Results: The highest visfatin, TNF-α and IL-1β levels were seen in insert ignore into journalissuearticles values(uDM+P+); group insert ignore into journalissuearticles values(p>0.001);. Significant positive correlations between GCF visfatin levels and GCF TNF-α and IL-1β levels were detected in insert ignore into journalissuearticles values(uDM+P+); group insert ignore into journalissuearticles values(p<0.001);. Conclusions: Elevated visfatin levels of serum, saliva and GCF in patients with DM and CP may be related with both diseases and interaction between DM and CP.
Keywords : Visfatin, TNF a, IL1 b, periodontitis, diabetes mellitus