Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats

Authors : Sedat DOGAN, Hasmet Yazici, Esin YALCİNKAYA, Halil İbrahim ERDOGDU

Pages : 11-15

Doi:10.18621/eurj.2016.5000202107

View : 16 | Download : 9

Publication Date : 2017-03-04

Article Type : Research Paper

Abstract :Objective. The aim of the present study was to investigate the protective role of selenium against cisplatin-induced oral mucositis in rats. Methods. Healthy wistar albino rats insert ignore into journalissuearticles values(n=21); were randomly divided into three groups: Cisplatin insert ignore into journalissuearticles values(Cis);, cisplatin and selenium insert ignore into journalissuearticles values(Cis+Se); and control insert ignore into journalissuearticles values(C);. Cisplatin was administered for 3 days to Cis and Cis+Se groups. Cis+Se group received selenium 5 days before cisplatin injection and continued for 11 consecutive days. Malondialdehyde insert ignore into journalissuearticles values(MDA); levels of the rats were determined before and at the end of experimental protocol. The tongues of rats were harvested for immunuhistochemical examinations. Results. In biochemichal analysis, MDA levels significantly increased in the Cis group insert ignore into journalissuearticles values( p =0.018);. On the contrary, there was no significant difference between pretreatment and posttreatment MDA levels in Cis+Se group insert ignore into journalissuearticles values( p =0.128);. In the immunohistochemical examinations of lingual tissues stained with anti-caspase-3, when the Cis and Cis+Se groups were compared, there were significantly more immunopositivity in the Cis group and significantly less immunopositivity in the Cis+Se group insert ignore into journalissuearticles values( p <0.05);. Conclusions. Selenium might have played a protective role against cisplatin-induced oral mucositis in rats. Further studies are necessary before its clinical use in patients.
Keywords : Cisplatin, oral mucositis, selenium, toxicity