Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model

Authors : Hasan Metineren, Turan Cihan Dülgeroğlu

Pages : 299-305

Doi:10.18621/eurj.373385

View : 21 | Download : 11

Publication Date : 2019-03-04

Article Type : Research Paper

Abstract :Objectives: Different materials are currently being used experimentally to accelerate cartilage healing and to obtain hyaline cartilage. We aimed to investigate the effect of platelet-rich fibrin on joint cartilage healing. Methods: Twenty rats were used in this study. platelet-rich fibrin was obtained from 4 rats, and the remaining 16 rats were randomly divided into two groups insert ignore into journalissuearticles values(4 and 8 weeks);. Both knee joints were prepared, and an osteochondral defect was created at the femoral condyle in all rats. platelet-rich fibrin was placed into the osteochondral defect of the right knee, while the left knee joint was used as a control. Groups were sacrificed after 4 and 8 weeks, respectively. Results: According to the O`Driscoll score, there were no significant differences between the right and left knee scores in group 4 weeks insert ignore into journalissuearticles values( p = 0.820); . However, the right knee scores were significantly different than the left knee scores in group 8 weeks insert ignore into journalissuearticles values( p < 0.001);. Defects were completely filled with cartilage tissue after 8 weeks in the platelet-rich fibrin group. Conclusions: Similar to its role in various tissues, platelet-rich fibrin is an effective biomaterial that enhances the healing of osteochondral defects. 
Keywords : Articular cartilage, chondral healing, experimental rat model, hyaline cartilage, platelet rich fibrin