Investigation of effects of neurotrophic factors on painful diabetic neuropathy: an experimental study

Authors : Faruk KILINÇ, Ramis ÇOLAK, Mete ÖZCAN, Ahmet AYAR

Pages : 641-648

Doi:10.18621/eurj.414105

View : 18 | Download : 11

Publication Date : 2019-07-04

Article Type : Research Paper

Abstract :Objective: We have studied the effects of neurotrophin-4 insert ignore into journalissuearticles values(NT-4); different doses on the pain levels of streptozocin-induced diabetic rats. Methods: Thirty-five 3-week-old male rats were used. After induction of diabetes in rats with streptozocin insert ignore into journalissuearticles values(nearly 4 weeks);; diabetic animals were divided into 4 groups. The first group; healthy control group insert ignore into journalissuearticles values(n = 15 );, the second group; diabetic control group insert ignore into journalissuearticles values( n = 10 );, the third group; low dose insert ignore into journalissuearticles values(0.3 mg/ kg ); recombinant human NT-4 was applied insert ignore into journalissuearticles values( n = 4 ); and the fourth group; high dose recombinant human NT-4 was applied insert ignore into journalissuearticles values(n = 6);. Results: In the low-dose NT-4 group, the pain threshold values did not differ from the diabetic control and healthy control groups. In the high dose NT-4 group, a rise was observed in the pain threshold values of hot plate in comparison with the healthy control group, diabetic control group and low dose applied group and this rise reached at the level of statistical significance insert ignore into journalissuearticles values( p < 0.05);. Conclusion: Neurotrophic factors insert ignore into journalissuearticles values(neurotrophin-4); have been shown to be effective on painful diabetic neuropathy in streptozocin-induced diabetic rats. However, there is a need for larger-scale and longer-term studies for clinical use. 
Keywords : Diabetic neuropathy, hot plate, neurotrophin 4, streptozocin