Dehydrated human amnion/chorion membrane allograft for preventing epidural fibrosis after laminectomy: an experimental rat model

Authors : Özhan Merzuk UÇKUN, Denizhan DİVANLIOĞLU, Rıfat AKDAĞ, Güner MENEKŞE, Ali DALGIÇ, Ahmet Deniz BELEN

Pages : 534-538

Doi:10.18621/eurj.523854

View : 23 | Download : 12

Publication Date : 2020-11-04

Article Type : Research Paper

Abstract :Objectives: Post-laminectomy syndrome due to epidural fibrosis insert ignore into journalissuearticles values(EF); is a common cause of persistent low back pain after lumbar spinal surgery and is challenging for both surgeons and patients. The current experimental study aimed to investigate the effect of dehydrated human amnion/chorion membrane insert ignore into journalissuearticles values(dHACM); allograft for preventing EF formation following lumbar laminectomy. Methods: Sixteen Sprague–Dawley rats equally divided into two groups underwent lumbar laminectomy. Group A, the control group, underwent lumbar laminectomy with standard closure. Group B, the experimental group, additionally received epidural dHACM allografts during the procedure. After 45 days of follow-up, the rats were sacrificed, and the harvested tissues were histopathologically evaluated for EF. Results: Compared with Group A, Group B showed significantly less EF generation insert ignore into journalissuearticles values( p < 0.001);, implying that dHACM allografts effectively prevent EF. Conclusions: This study demonstrated that dHACM can effectively reduce EF formation after spinal laminectomy in rats.
Keywords : Epidural fibrosis, laminectomy, amnion membrane allograft