The role of metformin on serum vitamin B12 levels in patients with type 2 diabetes mellitus

Authors : Mitra NİAFAR, Behrad JAMALİ, Nasrin LOTFİBAKHSHAİESH, Naser AGHAMOHAMMADZADEH, Nader NADER

Pages : 1-7

Doi:10.18621/eurj.2015.1.1.1

View : 56 | Download : 8

Publication Date : 2015-03-04

Article Type : Research Paper

Abstract :Objective.   To evaluate the vitamin B12 insert ignore into journalissuearticles values(VB12); deficiency in patients with type-2 diabetes mellitus insert ignore into journalissuearticles values(DM-2); using metformin or other hypoglycemic agents.  Methods.  400 patients with DM-2 were divided into two arms insert ignore into journalissuearticles values(N=200/group);; 1); those receiving metformin insert ignore into journalissuearticles values(MET); for at least six months and 2); those receiving  hypoglycemic agents other than metformin insert ignore into journalissuearticles values(OHA);. Serum VB12 concentrations were measured. Data were analyzed by using two-sample t-test for numerical data and chi-square with logistic regression analysis for categorical data. Numerical values were expressed as means ± standard deviations. Null hypotheses were rejected at P-values <0.05.  Results.  Definite biochemical VB12 deficiency insert ignore into journalissuearticles values(<148 pmol/L); was found in 29/200 insert ignore into journalissuearticles values(14.5%); of the MET group while it was observed in 4/200 insert ignore into journalissuearticles values(2%); in the OHA group insert ignore into journalissuearticles values(P<0.001);. Similarly, possible VB12 deficiency insert ignore into journalissuearticles values(serum concentrations <185 pmol/L); was found in 39 insert ignore into journalissuearticles values(19.2%); of the MET group and 12 insert ignore into journalissuearticles values(6%); in the OHA group insert ignore into journalissuearticles values(p<0.001);. There was positive correlation between low VB12 level and metformin administration insert ignore into journalissuearticles values(R 2 =0.26, p<0.001);.  Conclusion.  Patients with DM-2 on metformin had lower VB12 levels than those on other hypoglycemic drugs. The relation between VB12 deficiency and metformin therapy indicates the need for periodic measurement of serum VB12 levels in patients treated with metformin.
Keywords : Oral medications, type 2 diabetes, metabolic syndrome, HbA1C, diabetic neuropathy

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