Baseline characteristics of outpatients with heart failure according to phenotype: preliminary analysis from SMYRNA-HF registry

Authors : Bihter ŞENTÜRK, Ahmet ÇELİK, Lütfü BEKAR, Umut UYAN, Selcen yakar TÜLÜCE, Hakan GÜNEŞ, Murat KERKÜTLÜOĞLU, Ali ÇONER, Barış KILIÇASLAN, Nurullah ÇETİN, Ayşe ÇOLAK, Burak AÇAR, İlker GÜL, Cihan ALTIN, Yalçın ÖZKURT, Makbule KUTLU

Pages : 266-274

Doi:10.18621/eurj.1049360

View : 84 | Download : 5

Publication Date : 2022-03-04

Article Type : Research Paper

Abstract :Objectives: SMYRNA-HF study is a prospective multicenter registry study to determine the profiles of patients with heart failure insert ignore into journalissuearticles values(HF); in Turkey. This study aimed to present the baseline characteristics of preliminary cohort by comparing them according to different HF phenotypes. Methods: The first SMYRNA-HF cohort included outpatients with HF from 9 centers. Patients were classified into three HF phenotypes as HF with reduced ejection fraction insert ignore into journalissuearticles values(HFrEF);, mildly reduced EF insert ignore into journalissuearticles values(HFmrEF);, and preserved EF insert ignore into journalissuearticles values(HFpEF); as recommended by guidelines. Results: Overall, 298 patients were included in this preliminary analysis that 57% of the patients were classified as having HFrEF, 33.3% as having HFpEF, and 9.7% as having HFmrEF. Female gender was more common in HFpEF insert ignore into journalissuearticles values( p = 0.003);. Age, frequency of diabetes mellitus, use of angiotensin-converting enzyme inhibitors/angiotensin receptor blocker, use of beta-blocker, use of daily loop diuretic, heart rate, blood urea nitrogen levels, lipid profiles, hemoglobin, white blood cell, platelet levels were similar among three HF phenotypes. Body mass index insert ignore into journalissuearticles values(BMI); insert ignore into journalissuearticles values( p < 0.001);, frequency of hypertension insert ignore into journalissuearticles values(HT); insert ignore into journalissuearticles values( p < 0.001);, and atrial fibrillation insert ignore into journalissuearticles values(AF); insert ignore into journalissuearticles values( p = 0.015); were higher in HFpEF. Ischemic etiology insert ignore into journalissuearticles values( p < 0.001); was less frequent in HFpEF. Use of mineralocorticoid receptor antagonist was higher in HFrEF insert ignore into journalissuearticles values( p < 0.001);. Conclusions: Our study presented the baseline characteristics of outpatients with HF in Turkey. There were significant differences among HF phenotypes in terms of gender, BMI, frequency of HT, AF, and ischemic etiology. Treatment implementations seem to follow the guidelines. Although the rates are low, new treatment approaches recommended in the most recent guidelines seem to enter clinical practice.
Keywords : Heart failure, registries, Turkey, phenotypes, outpatients, baseline characteristics

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