Pathophysiology of metalloproteinase matrix in relation to morbid obesity and associated pathologies

Authors : Radu Mihail MİRİCA, Mihai IONESCU, Alexandra MIRICA, Octav GINGHINA, Razvan IOSIFESCU, Andrei Bogdan VACARASU, Danut Constantin CIOTARLA, Adrian ROSCA, Leon ZAGREAN, Niculae IORDACHE

Pages : 411-419

Doi:10.18621/eurj.1081324

View : 15 | Download : 8

Publication Date : 2022-05-04

Article Type : Review Paper

Abstract :Matrix Metalloproteinases insert ignore into journalissuearticles values(MMPs);, these calcium-dependent zinc-containing endopeptidases play an important role in adipogenesis and angiogenesis by modifying tissues and degrading the extracellular matrix insert ignore into journalissuearticles values(ECM);. Matrix glycoproteins, gelatin, collagens, proteoglycans and elastin are all found in the ECM. Current meta-analysis confirmed the lower levels of IL-6 and CRP was found following bariatric surgery. Several studies have shown correlations between E-selectin levels, BMI, and MMP-9 levels. There was also a strong link between the metalloproteinases MMP-2 and MMP-9. MMP-2 and adiponectin levels are related. MMP-9 levels, on the other hand, were modestly linked with E-selectin and HDL cholesterol levels, as previously stated. Also current observations imply that alterations in the ECM caused by MMP-mediated degradation may be crucial for the differentiation of adipocytes. The most crucial component of this is that MMPs are involved in the remodeling of tissue after gastric bypass surgery, as revealed by these markers insert ignore into journalissuearticles values(especially MMP-2 and MMP-9);. Thus, it is tempting to assume that adipocyte derived MMPs may constitute a novel pharmaceutical target for limiting adipose tissue development through the reduction of adipocyte differentiation and angiogenesis. MMP-2 exhibits far more accurate oscillations than MMP-9 during pre- and post-surgical weight fluctuations, and hence may be used as a predictor for gastric bypass success. The purpose of this paper is to conduct a comprehensive review of the literature with an emphasis on the critical functions that MMPs have in the pathophysiology of obesity and the related diseases.
Keywords : matrix metalloproteinase, morbid obesity, metabolic surgery, extracellular matrix