Protective effect of Tulbaghia violacea extract on cardiac damage: deep circulatory arrest rat model

Authors : Bişar AMAÇ, Nazım KANKILIÇ, Fatih GÜNGÖREN, Mehmet Salih AYDIN, Yusuf ÇAKMAK, Muhammet Emin GÜLDÜR, İsmail KOYUNCU, Emine Zeynep TARİNİ, Mesut ENGİN, Senol YAVUZ

Pages : 396-403

Doi:10.18621/eurj.1099649

View : 20 | Download : 6

Publication Date : 2022-05-04

Article Type : Research Paper

Abstract :Objectives: Total circulatory arrest insert ignore into journalissuearticles values(TCA); technique is a method used in cardiac surgery accompanied by cardiopulmonary bypass insert ignore into journalissuearticles values(CPB);. It has been shown that Tulbaghia violacea extract increases antioxidant capacity, regulates blood pressure, decreases lipid peroxide, and reduces atherosclerosis. In this experimental study, we aimed to investigate the effect of T. violacea extract administration on serum oxidative stress parameters insert ignore into journalissuearticles values(Total antioxidant status [TAS], total oxidant status [TOS] and oxidative stress index [OSI] and deoxyribonucleic acid [DNA] damage level with 8-Hydroxy-2-Deoxyguanosine [8-OHdG]); and histopathological changes in the heart and other organs in rats with deep circulatory arrest model. Methods: In this study, 48 Wistar Albino adult rats, 24 female and 24 male, obtained from Harran University Experimental Animals Research Center were used. The average weight of female rats was 250-300 g, and the average weight of male rats was 450-500 g. These rats were randomly divided into four groups. 6 male and 6 female rats were used in each group insert ignore into journalissuearticles values(Group 1 = Sham, Group 2 = Injury, Group 3 = Treatment and Injury, Group 4 = Treatment);. Results: As a result of this experimental study, the changes in the biochemical 8-OHdG, TOS, OSI and TAS levels of the groups were found to be statistically significant insert ignore into journalissuearticles values( p < 0.001);. In the subgroup analyzes of the data, 8-OHdG level, which is an oxidative DNA damage marker in Group 2 was higher than the Group 1, Group 3 and Group 4 and there was a statistically significant difference insert ignore into journalissuearticles values( p < 0.001, p = 0.027 and p < 0.001; respectively);. The TOS level of the injury group was higher than Group 1, Group 3 and Group 4 and there was a statistically significant difference insert ignore into journalissuearticles values( p < 0.001, p = 0.003 and p < 0.001; respectively);. Conclusions: As a result of our study, we revealed that T. violacea extract has a protective effect on organ and tissue damage in the TCA model.
Keywords : Circulation, arrest, protective agent, plant derived, Tulbaghia violacea extract