Comparison of biomarkers of COVID-19 patients with the alpha variant (B.1.1.7), the delta variant (B.1.617), and no mutation detected

Authors : Sanem KARADAĞ GENCER

Pages : 244-252

Doi:10.18621/eurj.1211808

View : 23 | Download : 6

Publication Date : 2023-03-04

Article Type : Research Paper

Abstract :Objectives: We aimed to compare biomarkers of COVID-19 patients with the Alpha variant insert ignore into journalissuearticles values(B.1.1.7);, the Delta variant insert ignore into journalissuearticles values(B.1.617);, and no mutation detected in our study. Methods: A total of 600 patients with positive COVID PCR test and Alpha, Delta variant and no mutation detected with Covid PCR mutation test were included in the study. Troponin I, creatinine, Alanine Aminotransferase insert ignore into journalissuearticles values(ALT);, Aspartate Aminotransferase insert ignore into journalissuearticles values(AST);, Lactate Dehydrogenase insert ignore into journalissuearticles values(LDH);, fibrinogen, D-dimer, ferritin, number of lymphocytes, lymphocytes insert ignore into journalissuearticles values(%);, platelet insert ignore into journalissuearticles values(PLT);, mean platelet volume insert ignore into journalissuearticles values(MPV);, platelet distribution width insert ignore into journalissuearticles values(PDW);, trombosite ratio in the blood insert ignore into journalissuearticles values(PCT);, C-reactive protein insert ignore into journalissuearticles values(CRP); values were analyzed retrospectively. The age, gender, and hospitalization of the patients were evaluated concurrently. Results: Age, troponin, creatinine, LDH, PLT, MPV, and D-dimer were laboratory parameters that vary significantly with COVID-19 virus mutation. Age, troponin, LDH, and MPV values were lower in patients with Delta variant according to patients with the Alpha variant. Lymphocytes insert ignore into journalissuearticles values(N); and lymphocytes insert ignore into journalissuearticles values(%); values were lower in hospitalized patients relative to outpatients while age, troponin, LDH, CRP, and D-dimer values were higher in hospitalized patients than outpatients irrespective of mutation. Creatinine values were higher only in hospitalized patients with no mutation detected while ferritin and fibrinogen values were higher in hospitalized patients with Delta variant and no mutation detected. Conclusions: Age, troponin, creatinine, LDH, PLT, MPV, D-dimer, fibrinogen, ferritin, CRP, lymphocytes insert ignore into journalissuearticles values(N);, and lymphocytes insert ignore into journalissuearticles values(%); values can guide to evaluate the diagnosis and hospitalization of patients with future different mutations.
Keywords : COVID 19, alpha, delta, mutation, biomarker

ORIGINAL ARTICLE URL