Here is the metastasis - find the primary carcinoma for it: a large biopsy study

Authors : Çiğdem ÖZDEMİR, Yiğit ŞENOL, Meltem BAYKARA, Mehmet Olgun AK, Hacer DEMİR, Yasin SARIKAYA

Pages : 309-316

Doi:10.18621/eurj.1240493

View : 27 | Download : 6

Publication Date : 2023-03-04

Article Type : Research Paper

Abstract :Objectives: According to estimates, cancer of unknown primary origin insert ignore into journalissuearticles values(CUP); accounts for approximately 3 to 5% of new cancer cases annually in the United States. With early diagnosis, many CUP patients can achieve long-term remission. The aim of this study was to document the organ tropism for metastasis for tumors with a definite primary cancer. In addition, we sought to contribute to understanding organ tropism in tumors of unknown origin. Methods: Retrospectively, biopsies of 492 metastatic cancers were evaluated. The required immunohistochemical panel was applied to determine the tumors’ origins. Results: A total of 492 patients with metastases were included in the study. The most common origins of metastasizing tumors were lung insert ignore into journalissuearticles values(25.4%);, colon insert ignore into journalissuearticles values(18.9%);, breast insert ignore into journalissuearticles values(15.4%); and stomach cancers insert ignore into journalissuearticles values(10.6%);. The least metastatic tumors were the salivary gland, neuroendocrine, adrenal, tubal, nasopharynx, rectum and esophagus cancers insert ignore into journalissuearticles values(0.22% for all);. The most common cancers that metastasized to the liver were colon cancer insert ignore into journalissuearticles values(29.0%);, stomach cancer insert ignore into journalissuearticles values(18.6%); and pancreatic cancer insert ignore into journalissuearticles values(18.6%);. The most common cancers that metastasized to the bone were lung cancer insert ignore into journalissuearticles values(58.0%);, breast cancer insert ignore into journalissuearticles values(29.0%);, and prostate cancer insert ignore into journalissuearticles values(13.9%);. The most common types of tumors that metastasized to the lungs, the kidney insert ignore into journalissuearticles values(35.1%);, colon insert ignore into journalissuearticles values(29.7%);, and breast cancers insert ignore into journalissuearticles values(16.2%);, were the most common. The most common tumors that metastasized to the brain were the lung insert ignore into journalissuearticles values(61.1%);, the breast insert ignore into journalissuearticles values(16.7%);, and kidney cancers insert ignore into journalissuearticles values(8.7%);. The most common tumors metastasizing to the skin were lung insert ignore into journalissuearticles values(31.0%);, breast insert ignore into journalissuearticles values(27.6%);, and colon insert ignore into journalissuearticles values(13.8%); cancers. Conclusions: Primary cancers have different metastatic patterns, which may help determine their causes. By involving distant anatomical structures and disrupting their function, tumor metastases increase the morbidity and mortality associated with the disease; thus, they affect staging, prognosis, and treatment. Metastases insert ignore into journalissuearticles values(or cancers from unknown primary sites); usually require extensive investigation to determine their primary source. Whether the cancer is tracked prospectively or retrospectively, a detailed observational template highlighting expected metastatic patterns would greatly assist in diagnosis and treatment.
Keywords : Cancer of unknown primary origin, organ tropism, metastasis

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