Comparison of human epidermal growth factor receptor 2 and cancer stem cell markers like CD44 and CD133 expressions with clinicopathological parameters in gastric cancer

Authors : Melin GECER, Nur BÜYÜKPINARBAŞILI, Seval TURNA, Mehmet BEŞİROĞLU, Zuhal GUCIN

Pages : 1015-1026

Doi:10.18621/eurj.1296567

View : 60 | Download : 74

Publication Date : 2023-09-04

Article Type : Research Paper

Abstract :Objectives: Gastric carcinoma insert ignore into journalissuearticles values(GC); is the fourth most common cause of cancer-related tumor deaths worldwide. The prognostic significance of CD44, CD133 and human epidermal growth factor receptor 2 insert ignore into journalissuearticles values(HER2); expression in GC remains controversial. Therefore, we aimed to investigate the relationship of CD44, CD133 and HER2 expression with clinicopathological features in metastatic and non-metastatic GC patients. Methods: A total of 139 patients with GC insert ignore into journalissuearticles values(68 with metastasis, 71 without metastasis); diagnosed were retrospectively analyzed. CD44 and CD133 expression were determined by immunohistochemical method in all cases. In addition, HER2 overexpression of the tumor was evaluated in patients with metastatic GC. Results: The CD133 positivity rate was 90.6% insert ignore into journalissuearticles values(n = 126); when all cases were considered, and that for CD44 was 84.9% insert ignore into journalissuearticles values(n = 118);. There was no difference in CD133 and CD44 positivity insert ignore into journalissuearticles values(intensity or density); rates and between the total scores of metastatic and non-metastatic patients with GC insert ignore into journalissuearticles values( p > 0.05);. HER2 positivity in metastatic cases was detected in 49 insert ignore into journalissuearticles values(70.1%); patients by immunohistochemical method. No correlation was found between CD133 total score and age, tumor size or depth, and HER2 scores in metastatic or non-metastatic cases insert ignore into journalissuearticles values( p > 0.05);. In the correlation analyzes performed with CD44 scores, only a borderline significant correlation was found between CD44 scores and tumor size insert ignore into journalissuearticles values(r:0.175; p = 0.047); in non-metastatic cases. Conclusions: We demonstrated associations between CD44/CD133 expression and histological grade in all patients, between CD44 and tumor size in non-metastatic patients, and between HER2 and intestinal type insert ignore into journalissuearticles values(Lauren); in metastatic patients. The results of this study need to be confirmed by multicenter studies including large case series.
Keywords : Stem cell, CD44, CD133, gastric cancer, HER2