Expression of roundabout receptor family members 1 and 2 in laryngeal squamous cell carcinoma and correlation with clinical and pathological parameters

Authors : Ayşe EREN, Ender COŞKUNPINAR, Kadir Serkan ORHAN, Deniz KANLIADA, Önder ŞAHİN, Mustafa Ömür KÖSE, Turgay İSBİR, İlhan YAYLIM

Pages : 26-33

View : 27 | Download : 11

Publication Date : 2018-03-05

Article Type : Research Paper

Abstract :Objectives: This study aims to investigate whether there is a role of ROBO-1, ROBO-2 and TGM-3 gene expression levels in the development of laryngeal cancer. Patients and Methods: The study was completed with 29 patients who underwent total or partial laryngectomy due to squamouscell laryngeal cancer. Gene expression analysis was performed by quantitative real-time polymerase chain reaction qRT-PCR . Expression ratios were transformed into fold changes and reported as relative expression. Obtained fold changes were compared between different tumor grades in addition to normal tissue samples. Results: The ROBO-1, ROBO-2 and TGM-3 genes were expressed at a lower level than the control group. Conclusion: Our study results showed that there was no correlation between ROBO-1, ROBO-2 and TGM-3 gene expression and development of laryngeal cancer.
Keywords : Gene expression, laryngeal carcinoma, Roundabout 1, TGM 3